Association of insomnia and daytime sleepiness with low back pain: A bidirectional mendelian randomization analysis

29th November, 2022

Peng Shu, Lixian Ji, Zichuan Ping, Zhibo Sun, Wei Liu

In Frontiers in Genetics
2 Citations

Disease areas: Digestive system
Types of data: Biomarkers, Lifestyle

Acknowledgements: We want to acknowledge the participants and investigators of UK Biobank, 23andMe and FinnGen study.

Low back pain (LBP) is one of the most common patient complaints in orthopedic outpatient departments and imposes a high burden on individuals and society. According to The Global Burden of Disease study 2013, chronic LBP is the most frequent cause of disability worldwide (Global Burden of Disease Study 2013 Collaborators, 2015). The prevalence of LBP has been estimated between 60% and 80% (Hagen et al., 1997). Chronic LBP is associated with many risk factors and diseases, such as overweight and obesity, heavy physical effort and depression (Nieminen et al., 2021). Nonetheless, its etiology is multifarious, and in 90% of back pain patients, the underlying reason cannot be identified. Therefore, better identification of LBP risk factors could help advance public health and reduce the cost of treatment.